S-14671

S-14671
Clinical data


ATC code	none
Identifiers
IUPAC name N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}thiophene-2-carboxamide
CAS Number	135722-27-9
PubChem CID	131907
IUPHAR/BPS	25
ChemSpider	116529
Chemical and physical data
Formula	C₂₂H₂₅N₃O₂S
Molar mass	395.52 g/mol

S-14671 is a naphthylpiperazine derivative which acts as a 5-HT_1A receptor agonist (pK_i = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT_2A and 5-HT_2C receptor antagonist (both are pK_i = 7.8). It displays only low and non-significant affinity for 5-HT_1B and 5-HT₃ sites.

In producing 5-HT_1A-mediated effects such as hypothermia and spontaneous tail flicks in rodents, S-14671 is active at doses as low as 5 µg subcutaneously, and is about 10-fold more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone. Other 5-HT_1A-mediated effects of S-14671 include induction of flat-body posture, corticosterone secretion, inhibition of morphine-induced antinociception, and attenuation of the electrical activity of the dorsal raphe nucleus.