SCNN1A

SCNN1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M3O
Identifiers
Aliases	SCNN1A, BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1, sodium channel epithelial 1 alpha subunit
External IDs	MGI: 101782 HomoloGene: 811 GeneCards: SCNN1A
Genetically Related Diseases
Gene ontology Molecular function • sodium channel activity • protein binding • ligand-gated sodium channel activity • WW domain binding Cellular component • integral component of membrane • cell projection • membrane • sodium channel complex • integral component of plasma membrane • cilium • ciliary membrane • motile cilium • extracellular exosome • plasma membrane • apical plasma membrane Biological process • sodium ion transmembrane transport • response to stimulus • sodium ion transport • ion transport • ion transmembrane transport • transport • sodium ion homeostasis • multicellular organismal water homeostasis • sensory perception of taste Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6337	20276
Ensembl	ENSG00000111319	ENSMUSG00000030340
UniProt	P37088	Q61180
RefSeq (mRNA)	NM_001159576 NM_001038 NM_001159575	NM_011324
RefSeq (protein)	NP_001029 NP_001153047 NP_001153048	NP_035454.2 NP_035454
Location (UCSC)	Chr 12: 6.35 – 6.38 Mb	Chr 6: 125.32 – 125.34 Mb
PubMed search

2M3O

6337

20276

ENSG00000111319

ENSMUSG00000030340

P37088

Q61180

NM_001159576
NM_001038
NM_001159575

NM_011324

NP_001029
NP_001153047
NP_001153048

NP_035454.2
NP_035454

The SCNN1A gene encodes for the α subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1B, SCNN1G, and SCNN1D.

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Wikipedia