SCNN1B

SCNN1B
Identifiers
Aliases	SCNN1B, BESC1, ENaCb, ENaCbeta, SCNEB, sodium channel epithelial 1 beta subunit
External IDs	MGI: 104696 HomoloGene: 133555 GeneCards: SCNN1B
Gene ontology Molecular function • sodium channel activity • protein binding • WW domain binding • ligand-gated sodium channel activity Cellular component • integral component of membrane • membrane • sodium channel complex • plasma membrane • integral component of plasma membrane • apical plasma membrane • extracellular exosome • cytoplasmic vesicle membrane • external side of plasma membrane • cytoplasmic vesicle Biological process • excretion • sodium ion transmembrane transport • response to stimulus • sodium ion transport • ion transport • ion transmembrane transport • transport • sodium ion homeostasis • multicellular organismal water homeostasis • sensory perception of taste Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6338	20277
Ensembl	ENSG00000168447	ENSMUSG00000030873
UniProt	P51168	Q9WU38
RefSeq (mRNA)	NM_000336	NM_001272023 NM_011325
RefSeq (protein)	NP_000327	NP_001258952.1 NP_035455.1 NP_001258952 NP_035455
Location (UCSC)	Chr 16: 23.28 – 23.38 Mb	Chr 7: 121.87 – 121.92 Mb
PubMed search

6338

20277

ENSG00000168447

ENSMUSG00000030873

P51168

Q9WU38

NM_000336

NM_001272023
NM_011325

NP_000327

NP_001258952.1
NP_035455.1
NP_001258952
NP_035455

The SCNN1B gene encodes for the β subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1G, and SCNN1D.

ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1A) represents that these are NON-voltage-gated channels.

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Wikipedia