SGEF

Src homology 3 domain-containing Guanine nucleotide Exchange Factor)
Identifiers
Symbol	SGEF
Alt. symbols	CSGEF, HMFN1864
Entrez	26084
RefSeq	NM_015595
UniProt	Q96DR7
Other data
Locus	Chr. 3 q25.2

SGEF (Src homology 3 domain-containing Guanine nucleotide Exchange Factor) is a 97 kDa protein involved in intracellular signalling networks. It functions as a guanine nucleotide exchange factor (GEF) for RhoG, a small G protein of the Rho family.

SGEF was discovered during a screen for androgen-responsive genes in human prostate cancer cells. Subsequent northern blot analysis revealed expression of SGEF in tissues of the heart, brain, placenta, lung, liver, kidney, pancreas, prostate, testis, small intestine and colon. SGEF is also expressed in endothelial cells of the vasculature. Several widely used cell lines express this protein, these include A431, HeLa, HUT78, HEK-293, Jurkat, THP, PC12, RAJI, U937 and Meg-01. SGEF was identified to contribute to the formation of atherosclerosis through promoting endothelial docking structures that resulted in retention of leukocytes at athero-prone sites of inflammation . Genetic variants variants in SGEF have been associated with coronary artery disease