Sodium chlorite

Sodium chlorite

Names
IUPAC name Sodium chlorite
Other names Chlorous acid, sodium salt Textone
Identifiers
CAS Number	7758-19-2 Y 49658-21-1 (trihydrate) N
3D model (Jmol)	Interactive image
ChEBI	CHEBI:78667 N
ChemSpider	22860 Y
ECHA InfoCard	100.028.942
EC Number	231-836-6
KEGG	C19523 N
PubChem	23668197
RTECS number	VZ4800000
UNII	G538EBV4VF Y
UN number	1496
InChI InChI=1S/ClHO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1 Y Key: UKLNMMHNWFDKNT-UHFFFAOYSA-M Y InChI=1/ClHO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1 Key: UKLNMMHNWFDKNT-REWHXWOFAT
SMILES [Na+].[O-]Cl=O
Properties
Chemical formula	NaClO2
Molar mass	90.442 g/mol (anhydrous) 144.487 g/mol (trihydrate)
Appearance	white solid
Odor	odorless
Density	2.468 g/cm3, solid
Melting point	anhydrous decomposes at 180–200 °C trihydrate decomposes at 38 °C
Solubility in water	75.8 g/100 mL (25 °C) 122 g/100 mL (60 °C)
Solubility	slightly soluble in methanol, ethanol
Acidity (pKa)	10-11
Structure
Crystal structure	monoclinic
Thermochemistry
Std enthalpy of formation (ΔfHo298)	-307.0 kJ/mol
Pharmacology
ATC code	D03AX11 (WHO)
Hazards
Safety data sheet	ICSC 1045
NFPA 704	0 1 1 OX
Flash point	Non-flammable
Lethal dose or concentration (LD, LC):
LD50 (median dose)	350 mg/kg (rat, oral)
Related compounds
Other anions	Sodium chloride Sodium hypochlorite Sodium chlorate Sodium perchlorate
Other cations	Potassium chlorite Barium chlorite
Related compounds	Chlorine dioxide Chlorous acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

Sodium chlorite (NaClO₂) is a chemical compound used in the manufacturing of paper and as a disinfectant.

The main application of sodium chlorite is the generation of chlorine dioxide for bleaching and stripping of textiles, pulp, and paper. It is also used for disinfection of municipal water treatment plants after conversion to chlorine dioxide. An advantage in this application, as compared to the more commonly used chlorine, is that trihalomethanes (such as chloroform) are not produced from organic contaminants. Chlorine dioxide generated from sodium chlorite is approved by FDA under some conditions for disinfecting water used to wash fruits, vegetables, and poultry.

Sodium chlorite, NaClO₂, sometimes in combination with zinc chloride, also finds application as a component in therapeutic rinses, mouthwashes, toothpastes and gels, mouth sprays, as preservative in eye drops, and in contact lens cleaning solution under the trade name Purite.

Under the brand name Oxine it is used for sanitizing air ducts and HVAC/R systems and animal containment areas (walls, floors, and other surfaces).

Neuraltus Pharmaceuticals is investigating a drug that they refer to as NP001 for treatment of amyotrophic lateral sclerosis. Some people with ALS have concluded that NP001 is a formulation of sodium chlorite, and are ordering the chemical and self-dosing outside of any scientific study. Preliminary results suggest that this sodium chlorite treatment is less effective than NP001. One seller of “Miracle Mineral Solution” (a mixture of sodium chlorite and water also known as "MMS") was recently convicted in the United States for marketing a toxic chemical as a miracle cure, as sodium chlorite cannot be legally sold for human consumption in the country.

In organic synthesis, sodium chlorite is frequently used as a reagent in the Pinnick oxidation for the oxidation of aldehydes to carboxylic acids. The reaction is usually performed in monosodium phosphate buffered solution in the presence of a chlorine scavenger (usually 2-methyl-2-butene).