TRIP6

TRIP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X61, 2DLO
Identifiers
Aliases	TRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDs	MGI: 1343458 HomoloGene: 37757 GeneCards: TRIP6
Gene ontology Molecular function • kinase binding • protein binding • interleukin-1 receptor binding • metal ion binding • thyroid hormone receptor binding • RNA binding Cellular component • cell junction • plasma membrane • interleukin-1 receptor complex • cytoskeleton • nucleus • focal adhesion • cytoplasm • cytosol Biological process • focal adhesion assembly • cell adhesion • regulation of transcription, DNA-templated • release of cytoplasmic sequestered NF-kappaB • transcription, DNA-templated • positive regulation of cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7205	22051
Ensembl	ENSG00000087077	ENSMUSG00000023348
UniProt	Q15654	Q9Z1Y4
RefSeq (mRNA)	NM_003302	NM_011639
RefSeq (protein)	NP_003293	NP_035769.1 NP_035769
Location (UCSC)	Chr 7: 100.87 – 100.87 Mb	Chr 5: 137.31 – 137.31 Mb
PubMed search

1X61, 2DLO

7205

22051

ENSG00000087077

ENSMUSG00000023348

Q15654

Q9Z1Y4

NM_003302

NM_011639

NP_003293

NP_035769.1
NP_035769

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

TRIP6 has been shown to interact with LPAR2,BCAR1 and HOXA9.

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Wikipedia