Tetherin

BST2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LK9, 2X7A, 2XG7, 3MQ7, 3MQ9, 3MQB, 3MQC, 3NWH, 4P6Z
Identifiers
Aliases	BST2, CD317, TETHERIN, Tetherin, bone marrow stromal cell antigen 2
External IDs	HomoloGene: 48277 GeneCards: BST2
Gene ontology Molecular function • protein homodimerization activity • signal transducer activity • protein binding • metalloendopeptidase inhibitor activity • RNA binding Cellular component • cytoplasm • integral component of membrane • multivesicular body • endosome • late endosome • Golgi apparatus • membrane • plasma membrane • integral component of plasma membrane • cell surface • apical plasma membrane • membrane raft • anchored component of membrane • extracellular exosome • cytosol • azurophil granule membrane Biological process • negative regulation of intracellular transport of viral material • regulation of actin cytoskeleton organization • response to interferon-gamma • immune system process • cell-cell signaling • response to virus • response to interferon-beta • multicellular organism development • B cell activation • negative regulation of viral genome replication • negative regulation of cell migration • humoral immune response • defense response to virus • type I interferon signaling pathway • negative regulation of cell growth • negative regulation of plasmacytoid dendritic cell cytokine production • response to interferon-alpha • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell proliferation • innate immune response • negative regulation of endopeptidase activity • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	684	n/a
Ensembl	ENSG00000130303	n/a
UniProt	Q10589	n/a
RefSeq (mRNA)	NM_004335	n/a
RefSeq (protein)	NP_004326	n/a
Location (UCSC)	Chr 19: 17.4 – 17.41 Mb	n/a
PubMed search		n/a

2LK9, 2X7A, 2XG7, 3MQ7, 3MQ9, 3MQB, 3MQC, 3NWH, 4P6Z

684

n/a

ENSG00000130303

n/a

Q10589

n/a

NM_004335

n/a

NP_004326

n/a

Tetherin, also known as bone marrow stromal antigen 2, is a lipid raft associated protein that in humans is encoded by the BST2 gene. In addition, tetherin has been designated as CD317 (cluster of differentiation 317). This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN pathway.

Tetherin is part of IFN-dependent antiviral response pathway. When the presence of virus and viral components is detected by recognition molecules such as (RIG-I), a cascades of interactions happen between signaling molecules, eventually the signal reaches the nucleus to upregulate the expression of interferon-stimulated genes (ISGs), this in turn activates IFN-a pathway to send the signal to neighboring cells, which causes upregulation in the expression of other ISGs and many viral restriction factors, such as tetherin.

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