| U.S. Route 421 | ||||
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| Route information | ||||
| Maintained by VDOT | ||||
| Length: | 69.23 mi (111.41 km) | |||
| Existed: | ca. 1950 – present | |||
| Major junctions | ||||
| South end: |
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| North end: |
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| Location | ||||
| Counties: | City of Bristol, Washington, Scott, Lee | |||
| Highway system | ||||
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US 11 / US 11E / US 19 / SR 381 in Bristol![]()
US 11W / SR 1 in Bristol![]()
I‑81 / US 58 in Bristol
SR 224 near Weber City
US 23 in Weber City
SR 65 in Clinchport
US 58 at Dot![]()
US 58 Alt. in Pennington Gap