Caspase 10

CASP10
Identifiers
Aliases	CASP10, ALPS2, FLICE2, MCH4, Caspase 10
External IDs	HomoloGene: 50038 GeneCards: CASP10
Gene ontology Molecular function • death effector domain binding • peptidase activity • cysteine-type endopeptidase activity • cysteine-type peptidase activity • protein binding • hydrolase activity • cysteine-type endopeptidase activity involved in apoptotic signaling pathway • ubiquitin protein ligase binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis Cellular component • ripoptosome • cytosol • CD95 death-inducing signaling complex Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • cell surface receptor signaling pathway • proteolysis • apoptotic process • regulation of apoptotic process • execution phase of apoptosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	843	n/a
Ensembl	ENSG00000003400	n/a
UniProt	Q92851	n/a
RefSeq (mRNA)	NM_001206524 NM_001206542 NM_001230 NM_001306083 NM_032974 NM_032976 NM_032977	n/a
RefSeq (protein)	NP_001193453 NP_001193471 NP_001221 NP_001293012 NP_116756 NP_116758 NP_116759	n/a
Location (UCSC)	Chr 2: 201.18 – 201.23 Mb	n/a
PubMed search		n/a

843

n/a

ENSG00000003400

n/a

Q92851

n/a

NM_032976
NM_032977

n/a

NP_116758
NP_116759

n/a

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Caspase 10 has been shown to interact with FADD,CFLAR,Caspase 8,Fas receptor,RYBP,TNFRSF1A and TNFRSF10B.

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Wikipedia