SEC62

SEC62
Identifiers
Aliases	SEC62, Dtrp1, HTP1, TLOC1, TP-1, SEC62 homolog, preprotein translocation factor
External IDs	MGI: 1916526 HomoloGene: 2449 GeneCards: SEC62
Gene ontology Molecular function • protein transporter activity • receptor activity Cellular component • integral component of membrane • cytosol • rough endoplasmic reticulum • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • protein transport • posttranslational protein targeting to membrane • IRE1-mediated unfolded protein response • cotranslational protein targeting to membrane • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7095	69276
Ensembl	ENSG00000008952	ENSMUSG00000027706
UniProt	Q99442	Q8BU14
RefSeq (mRNA)	NM_003262	NM_027016
RefSeq (protein)	NP_003253	NP_081292.1 NP_081292
Location (UCSC)	Chr 3: 169.97 – 170 Mb	Chr 3: 30.79 – 30.82 Mb
PubMed search

7095

69276

ENSG00000008952

ENSMUSG00000027706

Q99442

Q8BU14

NM_003262

NM_027016

NP_003253

NP_081292.1
NP_081292

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

...
Wikipedia