SEC63

SEC63
Identifiers
Aliases	SEC63, DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator
External IDs	MGI: 2155302 HomoloGene: 5220 GeneCards: SEC63
Gene ontology Molecular function • receptor activity • protein binding • protein transporter activity • RNA binding Cellular component • endoplasmic reticulum membrane • cytosol • integral component of membrane • membrane • endoplasmic reticulum Biological process • transport • IRE1-mediated unfolded protein response • protein targeting to membrane • liver development • protein transport • SRP-dependent cotranslational protein targeting to membrane • multicellular organism aging • renal system development • nitrogen compound metabolic process • posttranslational protein targeting to membrane • posttranslational protein targeting to membrane, translocation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11231	140740
Ensembl	ENSG00000025796	ENSMUSG00000019802
UniProt	Q9UGP8	Q8VHE0
RefSeq (mRNA)	NM_007214 NM_018529	NM_153055
RefSeq (protein)	NP_009145	NP_694695.3 NP_694695
Location (UCSC)	Chr 6: 107.87 – 107.96 Mb	Chr 10: 42.76 – 42.83 Mb
PubMed search

11231

140740

ENSG00000025796

ENSMUSG00000019802

Q9UGP8

Q8VHE0

NM_007214
NM_018529

NM_153055

NP_009145

NP_694695.3
NP_694695

Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

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