MYPN

MYPN
Identifiers
Aliases	MYPN, CMD1DD, CMH22, MYOP, RCM4, myopalladin, NEM11
External IDs	MGI: 1916052 HomoloGene: 23778 GeneCards: MYPN
Gene ontology Molecular function • SH3 domain binding • cytoskeletal protein binding • actin binding • protein binding • muscle alpha-actinin binding • actin filament binding Cellular component • cytoplasm • sarcomere • Z disc • I band • nucleus Biological process • sarcomere organization • regulation of cell migration • cardiac muscle fiber development • regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84665	68802
Ensembl	ENSG00000138347	ENSMUSG00000020067
UniProt	Q86TC9	Q5DTJ9
RefSeq (mRNA)	NM_001256267 NM_001256268 NM_032578	NM_182992
RefSeq (protein)	NP_001243196 NP_001243197 NP_115967	NP_892037
Location (UCSC)	Chr 10: 68.11 – 68.21 Mb	Chr 10: 63.12 – 63.2 Mb
PubMed search

84665

68802

ENSG00000138347

ENSMUSG00000020067

Q86TC9

Q5DTJ9

NM_001256267
NM_001256268
NM_032578

NM_182992

NP_001243196
NP_001243197
NP_115967

NP_892037

Myopalladin is a protein that in humans is encoded by the MYPN gene. Myopalladin is a muscle protein responsible for tethering proteins at the Z-disc and for communicating between the sarcomere and the nucleus in cardiac and skeletal muscle

Myopalladin is a 145.2 kDa protein composed of 1320 amino acids. Myopalladin has five Ig-like repeats within the protein, and a proline-rich domain. Myopalladin binds the Src homology domain of nebulette and nebulin and tethers it to alpha-actinin via its C-terminal domain binding to the EF hand domains of alpha-actinin. The N-terminal region of myopalladin binds to the nuclear protein CARP, known to regulate gene expression in muscle. It also has been shown to bind ANKRD23.

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Wikipedia